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act especially on neuromuscular structures, and the results of such action are generally in evidence long before cough or expectoration, or other indication of local lesion, is forthcoming. The chief error in the past has lain in too exclusive attention to the local manifestation, wherever presented, while too little purchase bactrim has been paid to the bacillarj' invasion as such. In this sense, the common separation between so called medical and surgical tuberculosis is artificial and unscientific. The tuberculized patient should be viewed pathologically and therapeutically from the same kind of standpoint as the syphilitic one ; each being the subject of a definite systemic infec- tion which is insidious, bactrim for mrsa tenacious, and protean in manifestation. If the pathological position pre- sented be conceded, the first great move toward effective treatment will be the adoption of a bactrim prices com- plete revision of the standard and methods of diag- nosis. The earliest manifestations of tuberculosis must be better defined and studied. Especially does the lymphatic stage require accentuation ; and fine multiple enlargement of glands must be searched for. Symptoms of neuromuscular intoxication must be viewed with bactrim bactrim care, and of special signifi- cance is genera! muscular dystrophy. In respect of visceral (more particularly pulmonary) antibiotics bactrim lesions, there is room for much greater refinement of diag- nosis than is usually practised or taught. Bacterio- logical evidence must not be restricted to the demonstration of the tubercle bacillus; if we wait for the actual appearance of the bacilli in dis- charges, we wait much too long. The more recent tuberculin bactrim and tests have contributed greatly to ease and exactness of diagnosis, and there are signs that we are within no great distance of more satisfac- tory serological tests. Accumulating experience at the tuberculosis dispensary led the author many bactrim generic years ago to institute what he termed the "march past" of the infected households, and the facts educed by this systematic examination led to the conclusion that tuberculosis was far commoner among children than had been supposed. If the principle of generic for bactrim the "march past" were universally car- ried out, not merely at the tuberculosis dispensary, but likewise in general practice, tuberculosis in its grosser forms would disappear. Tuberculosis has been shown to be most tractable, when taken in hand sufliciently early and sufficiently bactrim 800mg firmly. In speaking of direct therapeusis the author states that he has employed tuberculin continuously since i8qo. August 9. igijl 77 77/ OF PROGRESSIVE LITERATURE •'>7 with results proving it to be a specific remedy of great value, provided it is used early enough and properly administered long enough. Treatment of Hemorrhage in Typhoid Fever. — llardee johnslon deprecates the application uf the ice bag. raising the foot of the sulfa bactrim bed, and the use of opium. antibiotic bactrim The mrsa bactrim treatment which he has found most satisfactory is irrigation with three or four gallons of cold water, allowed to How slowly into and out of the rectum. Were the patient in severe shock from the hemorrhage, he would prefer to use warm w ater. .\s a rule, however, the first hemorrhage is not sufficient in amount to cause much shock ; though, of course, the ulcer might be bactrim and uti so located that the first hemorrhage would be the only one, and cause death, INTERSTATE MEDICAL JOURNAL. .'rciu-. /oi;. Kinetic bactrim tablets Theorj' of Surgical Shock and Anoci Association. — (i. W. Crile says that while we have long known that disturbance of any part of the vasomotor mechanism might cause sliock, it re- mained for an extended series of laboratory experi- ments and clinical observations to teach us that the vasomotor and otb.er disturbances were intermedi- ary between the cause and the effect. The key to the final cause of shock was found in a study of the phylogenetic bactrim 800 mg history, not of the vasomotor system alone, but of the whole motor mechanism. As a result of a train of reasoning and certain researches, he formulated what he calls his "kinetic theory of surgical shock." This assumes a number of points, among which are the following : That traumatic stimuli of sufficient number and intensity lead inevitably to exhaustion and bactrim price death : and that bactrim 400 mg when the expenditure of energy caused by emotional stimuli cannot take its normal course and produce motor activity, the condition reacts upon itself ; the stimulation thus being automatically increased, and the resultant expenditure of potential energy pro- portionately active. The final condition in either of these two instances is designated shock. In solving the question, \Miy is not the administration of an inhalation anesthetic a sufficient preventive of shock? cost of bactrim the author made a series of experiments upon animals which showed conclusively that if the connection between the brain and the traumatized ])art could be broken, the brain cells would be pro- tected from damage ; and he found that this could be accomplished by a thorough infiltration of the tissues to be bactrim cost traumatized with a local anesthetic. By the use of a nonoxidizing general anesthetic, nitrous oxide, and of a local anesthetic, novocaine, he achieved the thorough protection of the brain cells from danger during the course of the opera- tion itself. As psychic strain may be as active as actual trauma in producing shock, the search was made for a drug or drugs which would do away with the preoperative dread of the approaching ordeal, and it was found that morphine and scopo- lamine, in physiological doses, prevent psychic shock. If one could now discover a procedure which would diminish or eliminate postoperative ^uf?ering, the protective cycle would be complete ; and bv continued experimentation he found that this end could be secured hv an infiltration of the

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