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such attempts. The frequent association of at times serious mental depression Cytoxan Cyclophosphamide and melancholia is a fact which has been insufficiently noted in the literature on the subject. A considerable proportion of Cytoxan Tablets the patients I have seen were extremely sensitive about their condition, this sensitiveness amounting at times to the highest Cytoxan Taxotere degree of mental anguish. One of my patierlts gave up a very lucrative position, shunned all her acquaintances, refused to go out unless heavily veiled, and slowly drifted into true melan- cholia, because of her excessive polytrichia. Her mental condition became entirely normal after the removal of the superfluous hair. The amount of mental suffering which Taxotere And Cytoxan these patients go Buy Cytoxan Online through is surprisingly great, judging from their gratitude after recovery. There are only two plausible theories as to the causation of this anomaly, namely, hereditv and functional or organic disorders of the uteroovarian >ystem. That there are a number of instances of this Cytoxan Generic condition arising in generations of one family cannot be denied. Even universal congenital hirsu- ties has been observed in some families, a good ex- ample being the much quoted "Russian dogfaced man'' (Andrian Jeftichjeff) and his son; but, in spite of the.se instances, I do not believe heredity plays an important role in the causation of hirsuties. I have, through the courtesy of Dr. L. Duncan Bulkley, been enabled to combine some of his clin- ical histories with mine, and have a total of one 314 BECHET: ETIOLOGV ASD TREATMENT OE HYPEKIKICIIOSIS. [New York M EDicAL Journal. hundred and forty-six cases, in whicli etiological factors have been thoroughly gone into, and there are surprisingly few in which heredity seemed to be a possible Cytoxan Adriamycin cause. Time and again patients deny any family history of hypertrichosis. Of course, it cannot be gainsaid that, in some families, especially of the brunet type, excessive hair growth is com- mon, but it does not invariably develop into a no- ticeable hirsuties. The connection between hypertrichosis and the internal organs of generation is, in my opinion, a much closer one — for instance, the growth of hair on the male chin and lip, which occurs only at, and slightly beyond puberty, is certainly the result of the action of some new formed unknown secretion, probably of testicular origin. The influence of the uteroovarian system and normal sexual life is well brought out in the analysis of the cases previously alluded to. Of 146 cases analyzed, 106 patients were unmarried. In none of Cytoxan And the Cytoxan And Adriamycin cases did hyper- trichosis occur before the establishment of puberty. Of the 106 single women, only four were less than eighteen years of age — two were sixteen, one fif- teen, and one fourteen ; Adriamycin And Cytoxan in all four puberty was well established. In noting the number of abnormal menstruations I have endeavoured to be most conservative, and have been careful to exclude all but the most serious abnormalities, so that, of the 146 cases, eighty patients were found to have severe menstrual disturbances, but fully twenty-five per cent, of the si.xty-five remaining patients had minor anoma- lies of menstruation. A considerable number of cases of spontaneous disappearance of superfluous hair after pregnancy, or the reestablishment of the normal flow following a prolonged amenorrhea, have been reported. Jackson observed Buy Cytoxan a woman who, after having borne several children, suffered from a persistent amenorrhea, during which time an extensive hirsuties developed. Several years later she again became pregnant, and, after the birth of the child, the growth spontaneously disap- peared. Hyde reported a married woman, thirty- three years of age, mother of three children, who had not menstruated for over a year. She had a general and facial hirsuties. After some years she began to menstruate, Oral Cytoxan and the hypertrichosis of the general surface spontaneously disappeared — the fa- cial hirsuties having Cytoxan And Taxotere been previously removed by electroylysis. In all reported cases of the early development of pubic hair, menstruation apparently invariably occurred. Lesser reports a girl of six with extensive hair growth, who had been menstru- ating since the age of three. In view of all these facts, it seems to me perfectly plausible to believe Cytoxan Oral that hypertrichosis is the result of a functional or organic derangement of the ovaries, whereby some unknown hormon, with a specific influence on pi- losity, is so altered in character that pilosis results. For the permanent and safe removal of superflu- ous hair nothing has as yet been able to supersede the operation of electrolysis. The x ray at first promised brilliant results, and most enthusiastic Adriamycin Cytoxan re- ports Cyclophosphamide Cytoxan were made, but the subsequent dermatitis, atrophic changes, or telangiectasis which so fre- (|uentlv followed its application, caused a reversal of the favorable opinion first held, and many now refuse to use it. Considering that the removal of superfluous hair is entirely a matter of cosmetics, one should hesitate to use sucli a powerful Iv Cytoxan agent, so capable of ultimate harm. It should be used only in those cases not otherwise amenable to treat- ment, and the exposures made by an expert only. As Norman Walker aptly says, "No beginner should use the x ray for this condition save in his own family." Electrolysis, on the other Taxotere Cytoxan hand, is entirely harm- less, and, in the hands of the skilled, results are per- manent and perfectly satisfactory. Poor results are entirely caused by inexperience Order Cytoxan on the part of the operator. There is no dermatological procedure

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