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SECRETIN AS A REMEDY IN tiASTROlN- Acetazolamide Diamox TESTINAL DISORDERS. P.Y Henry R. II.\rrovver, M. D., London, England. Laic Professor of Clinical Diagnosis, Loyola University, Chicigo, ni. For many years preparations of animal origin have taken an important place in the orthodox treat- ment of certain forms of indigestion. The use of pepsin and pancreatin has been established on a firm basis, although at times dissentient voices are heard to the effect that the continued use of such preparations tends to induce laziness on the part of the organs in question. Our conception of the treatment of the indigestions has in the past few years been very materially modified. The discovery of certain other substances also of animal origin has begun a revolution, not only in our conception of the physiology of the digestive glands, but in the treatment of their functional disorders. The most Order Diamox notable of these remarkable substances is the hormon "secretin," first isolated by Starling and Bayliss in the research laboratories of Univer- sity College, London, in i()02 (i). It would appear that in this substance we have a most valuable and reasonable remedy for many forms of indigestion ; a recapitulation, therefore, of some of the funda- mental facts regarding its application is appropriate. Hitherto experimental investigators have used this substance, and these, usually, not in clinical work. It is still the exception to find physicians using secretin as a therapeutic agent. Secretin is a definite chemical product of the mucous membrane of the pyloric end of the stomach and the duodenum. The story of its discovery may be briefly recalled : On the investigation of the properties of enterokinase, that remarkable tryptic activator first discovered in PavlofT's laboratories at St. Petersburg, Bayliss and Starling noted that the injection of acid or acid chyme into a loop of small intestine was followed by a secretion of pancreatic juice, even when all nerve channels had Buy Cheap Diamox been de- stroyed. These investigators were convinced that the message from the intestine to the pancreas was not carried by the nervous system, but by the blood ; they presumed, therefore, that the activating sub- stance was produced in the duodenal walls under the influence of the acid, and that it was then ab- sorbed Diamox Acetazolamide into the blood and served to excite pancreatic function. A portion of the intestinal mucous mem- brane was accordingly scraped, pounded up with dilute hydrochloric acid, and filtered. Injection of a portion of the neutralized filtrate into the blood of an animal resulted in a copious flow of pancreatic juice, and the chemical messenger or hormon responsible for this Generic Diamox action was nairied "secretin." Later Diamox Tablets it was called "pancreatic secretin," to distin- guish it Diamox 125 Mg from other similar substances which excited other glands (2). .Since this epoch making announcement was made other investigators, notably Edkins (3), have shown that the gastric walls near the pylorus produce a similar secretin which has been called "gastrin" or "gastric secretin." Its action is through the blood and upon the peptic and oxyntic glands of the stomach. 3i6 H.lKROlfliR: SliCKl-.TIX IX OASTROl XTI-STl X. U. HISOKDERS. Tn a recent editurial reference to The ( lastnc Secretin (4), tlie results of this work arc outlined as follows : Edkins has carried out experiments to see whether such a chemical mechanism, in distinction from the nervous control which is usually called on to elucidate the phenom- ena of secretion, may not also serve to explain the secre- tion of the gastric juice when food is introduced into the stomach. Diamox Mg He finds that substances such as Iv Diamox peptones, broths, dextrin, etc.. which are known to induce gastric secretion when Order Diamox Online ingested, are without influence on the secretory act if thev are injected directly into the blood stream. But when such known excitants of secretion are allowed to stay in contact with the pyloric mucous mem- brane, and a decoction of this is then injected mto the circulation, a secretion of both acid Purchase Diamox and peptic enzyme into the stomach ensues. Infusions of the cardiac poition of the stomach or of other organs do not act m this secretion producing manner. Edkins concludes that this typical secretion of gastric juice is determined by a chemi- cal mechanism; the first products of digestion act on the pyloric mucous membrane, in which they produce a sub- stance which, entering the blood stream, is carried to the gland cells of the stomach, where it acts as a specific ex- citant of their secretory activity. This is the gastric hormon — gastric secretion. The .St. Petersburg School has long opposed the ■■secretin theon,'." Bylina. in 191 1 (5). intimated that secretin was not quite what Bayliss and Star- ling had made out, stating that the _ pancreas possesses a constant secreting function for which nervous influences are principally responsible. Later (6), he admits that the pancreatic secretion to a certain extent is dependent upon a humoral mechanism ; but he still Tablet Diamox asserts that nervous in- fluences are concerned in the excitation of pan- creatic secretion and, indeed, Purchase Diamox Online determine the chemical character of the juice. L. B. Popielski Diamox 500mg Diamox Generic insisted similarly that secretin played a minor part in the activation of pancreatic juice, and Diamox Buy that the results purported to be due to its influence were obtainable Diamox 500 in other ways. Experiments seem to discount these statements, and the most conclusive proof of the fallacy of Diamox Sequels 500 Mg Bylina's idea is to be_ found Buy Diamox in a 100 page thesis (7) which gives the details and

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