SECRETIN AS A REMEDY IN tiASTROlN- Acetazolamide Diamox
TESTINAL DISORDERS.
P.Y Henry R. II.\rrovver, M. D.,
London, England.
Laic Professor of Clinical Diagnosis, Loyola University,
Chicigo, ni.
For many years preparations of animal origin
have taken an important place in the orthodox treat-
ment of certain forms of indigestion. The use of
pepsin and pancreatin has been established on a
firm basis, although at times dissentient voices are
heard to the effect that the continued use of such
preparations tends to induce laziness on the part of
the organs in question. Our conception of the
treatment of the indigestions has in the past few
years been very materially modified. The discovery
of certain other substances also of animal origin
has begun a revolution, not only in our conception
of the physiology of the digestive glands, but in the
treatment of their functional disorders.
The most Order Diamox notable of these remarkable substances
is the hormon "secretin," first isolated by Starling
and Bayliss in the research laboratories of Univer-
sity College, London, in i()02 (i). It would appear
that in this substance we have a most valuable and
reasonable remedy for many forms of indigestion ;
a recapitulation, therefore, of some of the funda-
mental facts regarding its application is appropriate.
Hitherto experimental investigators have used this
substance, and these, usually, not in clinical work.
It is still the exception to find physicians using
secretin as a therapeutic agent.
Secretin is a definite chemical product of the
mucous membrane of the pyloric end of the stomach
and the duodenum. The story of its discovery may
be briefly recalled : On the investigation of the
properties of enterokinase, that remarkable tryptic
activator first discovered in PavlofT's laboratories at
St. Petersburg, Bayliss and Starling noted that the
injection of acid or acid chyme into a loop of small
intestine was followed by a secretion of pancreatic
juice, even when all nerve channels had Buy Cheap Diamox been de-
stroyed. These investigators were convinced that
the message from the intestine to the pancreas was
not carried by the nervous system, but by the blood ;
they presumed, therefore, that the activating sub-
stance was produced in the duodenal walls under
the influence of the acid, and that it was then ab-
sorbed Diamox Acetazolamide into the blood and served to excite pancreatic
function. A portion of the intestinal mucous mem-
brane was accordingly scraped, pounded up with
dilute hydrochloric acid, and filtered. Injection of
a portion of the neutralized filtrate into the blood
of an animal resulted in a copious flow of pancreatic
juice, and the chemical messenger or hormon
responsible for this Generic Diamox action was nairied "secretin."
Later Diamox Tablets it was called "pancreatic secretin," to distin-
guish it Diamox 125 Mg from other similar substances which excited
other glands (2).
.Since this epoch making announcement was made
other investigators, notably Edkins (3), have shown
that the gastric walls near the pylorus produce a
similar secretin which has been called "gastrin" or
"gastric secretin." Its action is through the blood
and upon the peptic and oxyntic glands of the
stomach.
3i6
H.lKROlfliR: SliCKl-.TIX IX OASTROl XTI-STl X. U. HISOKDERS.
Tn a recent editurial reference to The ( lastnc
Secretin (4), tlie results of this work arc outlined
as follows :
Edkins has carried out experiments to see whether such
a chemical mechanism, in distinction from the nervous
control which is usually called on to elucidate the phenom-
ena of secretion, may not also serve to explain the secre-
tion of the gastric juice when food is introduced into the
stomach. Diamox Mg He finds that substances such as Iv Diamox peptones,
broths, dextrin, etc.. which are known to induce gastric
secretion when Order Diamox Online ingested, are without influence on the
secretory act if thev are injected directly into the blood
stream. But when such known excitants of secretion are
allowed to stay in contact with the pyloric mucous mem-
brane, and a decoction of this is then injected mto the
circulation, a secretion of both acid Purchase Diamox and peptic enzyme
into the stomach ensues. Infusions of the cardiac poition
of the stomach or of other organs do not act m this
secretion producing manner. Edkins concludes that this
typical secretion of gastric juice is determined by a chemi-
cal mechanism; the first products of digestion act on the
pyloric mucous membrane, in which they produce a sub-
stance which, entering the blood stream, is carried to the
gland cells of the stomach, where it acts as a specific ex-
citant of their secretory activity. This is the gastric
hormon — gastric secretion.
The .St. Petersburg School has long opposed the
■■secretin theon,'." Bylina. in 191 1 (5). intimated
that secretin was not quite what Bayliss and Star-
ling had made out, stating that the _ pancreas
possesses a constant secreting function for which
nervous influences are principally responsible.
Later (6), he admits that the pancreatic secretion
to a certain extent is dependent upon a humoral
mechanism ; but he still Tablet Diamox asserts that nervous in-
fluences are concerned in the excitation of pan-
creatic secretion and, indeed, Purchase Diamox Online determine the chemical
character of the juice. L. B. Popielski Diamox 500mg Diamox Generic insisted
similarly that secretin played a minor part in the
activation of pancreatic juice, and Diamox Buy that the results
purported to be due to its influence were obtainable Diamox 500
in other ways.
Experiments seem to discount these statements,
and the most conclusive proof of the fallacy
of Diamox Sequels 500 Mg Bylina's idea is to be_ found Buy Diamox in a 100
page thesis (7) which gives the details and
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