tion of the production of secretin in the duodenum.
why should not, clinically, a large number of dys-
pepsias be secondary to a disturbance in the highly
specialized function of the duodenal mucosa.''
When it is remembered," he continues, "'that
secretin also possesses an incontestable influence
upon intestinal motility, one of the first and most
constant signs of .secretin insufficiency must with-
out doubt be clinically represented by constipation.
Thus, g-uided by our experimental research, we
have found a means of stimulating this function
in certain constipated Dilantin 500 Mg dyspeptics." Enriquez Dilantin 1 G pre-
pared keratin coated capsules of gluten, containing
an active and harmless acid (tartaric), which was
proved experimentally to be stable in the stomach
and easily destroyed in the Dilantin Ex duodenum.
The Dilantin 400 Mg results of this form of medication were
most interesting. All the patients showed a more
or less noticeable constipation, and in seven of the
cases it was the dominating symptom, Dilantin 230 Mg inconven-
iencing the patients as much by its persistence as
by its obstinacy. In these seven cases acid meclica-
tion of the duodenum brought about, with varying
ease, according to the dose, a stimulation of the
secretory and motor functions of the intestine and
a regulation of the stools. Two cases were of
.special interest. One was that of a person suffer-
ing from localized sclerosis {"sclerose en plaques")
for many years, with intractable constipated
periods lasting from six to eight days, and which
resisted all kinds of jmrgatives, enemas Dilantin Xr only hav-
ing any action. Under this treatment the stools
were immediately regulated, giving way again to
constipation as soon as the treatment ceased, this
occurring several times. In five of the observa-
tions mucomembranous colitis was complicated
alternately with constipation and painful abdominal
crises, terminating by the passage of glairy mucous
and membranous Dilantin 130 Mg casts. In four of the cases the
colitic symptoms were nuich relieved at the same
time as the constipation.
Of course, the principal value of the method of
treatment outlined above depends upon the pro-
duction of secretin. There may be cases in which
the duodenal cells will not be stimulated, and here
it would seem that secretin itself could be used
to good advantage. I have personaly noticed, and
my experience has been confirmed by several corre-
spondents, that the administration of preparations
of secretin is followed quite Dilantin 330 Mg constantly by the relief
of fermentation and flatulence in the upper bowel,
and the reason for this is not far to seek. The
principrd cause of gastric and intestinal fermenta-
tions is a deficiency in the amount and activitv of
the digestive juices. It has long been known that
the administration of hydrochloric acid not only
favors the digestive action in the stomach, but also
tends to increase the amount of pancreatic fer-
ments in the duodenum, and only since the discov-
ery of sccreiin has ii been clear how this is brought
about.
\'ery little clinical work seems to have been
done with secretin in Dilantin 150 Mg the United States. The only
article' referring to a secretin preparation that I
iiave been able to find is from the pen of Board-
man Reed f 21 ). In this article he compares his stand-
ard pejisin hydrochloric mixtures, Dilantin Pharmacology referred to in
his excellent Ixxik.^ with an elixir containing gas-
tric and pancreatic Dilantin 30 Mg secretins, and finds that these
organic principles are considerably more active,
rapidly bringing the work of the stomach to the
normal, and, usually, at the same time improving
the intestinal indigestion and assimilation. Dilantin 125 Reed
states that secretogen is apparently the most pow-
erful excitant of gastrointestinal secretion so far
tried by him, and refers to a number of cases, one
of which is mentioned in an addendum to his paper,
which follows: "Since the foregoing was written
I have examined chemically the stomach contents
of one of the patients referred to, in which none of
the secretogen has been taken for a month, and
the proportions of both the free and combined
hydrochloric acid were found still a little above
normal, though, before the remedy was taken,
there had been no free hydrochloric acid at all, and
the Too Much Dilantin proportions of both the combined hydrochloric
acid, and of the total acidity, had been decidedly
below normal."
Moore (22) of the Biochemical Department of
Liverpool University, has called attention to deficient
secretin production in cancer and gastric cancer.
It is well known that achlorhydria is an almost
constant s^'mptom of this disease, and the lack of
hydrochloric acid — Cheap Dilantin the physiological stimulus to nor-
mal secretin production in the duodenal walls — re-
sults in a marked decrease in the amount and effec-
tiveness Dilantin 50 Mg of pancreatic ferments. This nearly suf-
fices to account for the nutritional disorders which
are pathognomonic of carcinoma. With the fore-
going in mind, it can be readily appreciated that
secretin may be used in cancer and cachexias gen-
erally, not to influence the disease per se, but
rather as a means of increasing the digestive activ-
ities and nutrition. The same ideas naturally hold
good in other conditions where toxemia, superfunc-
tion, or asthenia, has lessened the digestive
capacity. In no disease is this influence more de-
sirable than 'm tuberculosis, and attention is already
being turned to the possibilities of this new ad-
junct remedy for tuberculosis (23).
Secretin has been recommended as a means of
treating diabetes, and much was expected from its
use because several very good results occasionally
followed its early administration in Dilantin 200 Mg this disease.
The basis of this study was the clear physiological
evidence of a connection between pancreatic activ-
itv and diabetes, as well as between secretin and
|iancreatic activity, and that where functional dis-
order of the pancreas was present advantage might
be expected to follow the stimulus caused bv
secretin. In their first communication on this sub-
ject, Moore, Edie, and Abram (24), Dilantin 350 Mg described three
cases of diabetes in which improvement follow^ed
'The writer has drawn special attention to the possibilities Dilantin 600 Mg of
secretin as a Dilantin 250 Mg factor in the control of the summer indigestions of
infants (20).
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