oS-'
EDITORIAL ARTICLES.
PARINAUD'S COXJ L'NCTI VITIS.
Since Parinaud described in 1889 a peculiar dis-
ease of the conjunctiva associated with swelHns^s
of the lymphatic glands on the saine side of the
neck, a number of cases have been reported and its
etiology has excited some discussion. Quite a
number of writers have been insistent that the dis-
ease w^as a modified form of tuberculosis of a be-
nign type in spite of the facts that it runs a self
limited course, that the conjunctiva was not ulcer-
ated, that inoculations of conjunctival tissue fre-
quently failed to produce tuberculosis, that the
tubercle bacilli were not usually found in the
glands, that the proportionate number of patients
in whom the tuberculin reaction was positive did
not seem to be abnormally great, and that the his-
tological examination of the tissue always appeared
to indicate an infective origin. Those who did not
accept Buy Remeron Online this theory were obliged to content them-
selves with pointing out the objections to it, and
with the hope that some day the morbific agent
would be discovered. Dr. F. H. Verhoeff presents
in the Archives of Ophthalmology, for July, the rea-
sons which lead him to believe that he had discov-
ered this agent. Incidentally he Remeron Cost holds that certain
atypical cases of conjunctival tuberculosis may be
mistaken for Parinaud's conjunctivitis, and have
been reported as such, but that they do not possess
its characteristic histological features. The charac-
teristic feature is the occurrence of focal areas,
varying in size and shape, infiltrated with endo-
thelial phagocytes in various stages of necrosis, not
packed close together and united with each other,
as in tuberculosis, but discrete. The necrosis in-
volves the cells alone and bears no resemblance to
the caseation of tuberculosis. Surrounding these
areas the tissue is densely infiltrated with plasma
cells, t )rdinary granulation tissue also is formed,
the amount depending on the duration of the pro-
cess. In eleven of his twelve patients he found with-
in these areas of cell necrosis Purchase Remeron Online minute, filamentous
microorganisms, for the most part in Mirtazapine 15 Mg masses and
intertwined about one another, though separate in-
dividuals also could be seen, by means of a technic
that he describes in full detail. In one case, evi-
dently an early one, numerous masses were to be
seen in the superficial lymph spaces, and were 15 Mg Mirtazapine es-
pecially prominent just beneath the epithelium,
where the areas of cell necrosis usually occur.
Such masses apj>ear to be the starting points for
areas of cell necrosis, for all the stages in the
formation of the latter could Cheap Remeron be Order Remeron Online made out, begin-
ning with the invasion of a mass of microorgan-
isms by a few Endothelial cells, and this one case
alone seems to him to be sufficient to exclude the
i)ossibiIitv that these microorganisms are secondar\-
invaders. Their predilection for the lymph spaces
explains the early involvement of the regional
glands. Since no branching of the filaments could
be detected he classes the microorganism as a lep-
tothrix, and, so far as he knows, no similar one
l)athogenic for man has previously been described.
The unusual character of these Buy Remeron organisms, their
great abundance, the fact that they were situated
so as to explain the lesions, and the absence of any
others that were demonstrable, lead him to believe
them to be the causative agents of this peculiar dis-
ease. This can be made certain only by successful
cultivation on artificial media, and the experimental
production of the disease, preferably in monkeys.
ACTIVE IMMUNIZATION AGAINST
DIPHTHERIA.
There Mirtazapine 30 is no phase of immunity of greater practical
importance Generic Remeron than the active immunization against
infectious diseases. Important as the curative
serums are, they nevertheless constitute merely a
therapeutic agent. Valuable, it is Remeron Tablets true, but one
which falls short of the ideal of imitating Nature in
her lasting protection of races and individuals
against infectious diseases. After all, prophylaxis
is the ideal toward which we are striving, and any
measure which brings us nearer to the goal consti-
tutes an Remeron Price important advance along the line of battle
that is being waged against the pathogenic bacteria.
It is for this reason that Jenner's vaccination Order Remeron
against smallpox has remained Mirtazapine Mg the classical example
of active immunization. It showed the way. Remeron Online Pas-
teur's labors along the line of active immunization
also furnished a clue, while the recent researches of
Wright opened up a vista of great possibilities in
the prevention as well as the cure of infections.
In a recent contribution to the Ronsski Vratch
(May 4, 1913) S. K. Dzerzhgovsky relates an inter-
esting instance of a horse preserving its immunity
against diphtheria for sixteen years, or almost its
natural life. This horse served for the production
of antitoxine and was sold. Sixteen years later it
was repurchased and injected intravenously with
12,500 minimum fatal doses to guineapigs, this
being the maximum amount of diphtheria toxine the
liorse received during the last immunization. No
reaction followed. Purchase Remeron A second subcutaneous injec-
tion of the same quantity was followed by a slight
general and local reaction. The horse was then
bled, and the serum was found to contain 300
units of antitoxine to each cubic centimetre or
about four times the strength this Remeron Mg horse yielded
during the first immunization sixteen years Buy Cheap Remeron before. Mirtazapine 15
A similar result was obtained with a dog which was
immunized against diphtheria for a period of thir-
i-.ni tori.il articles.
i^i
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